Debby Ryan (Patty) and Chloe Bridges (Roxy) are friends in real life, and met whilst filming The Longshots (2008). They have also acted in Daytime Divas (2017) together, making Insatiable their third collaboration.
Drew Barrymore was mentioned in the first episode as an influence, in the Amy Fisher movie. Alyssa Milano, who plays Coralee also plays Amy Fisher in the TV movie "Casualties of Love: The Long Island Lolita Story" in 1993. Another fun fact, Alyssa went into play in Poison Ivy 2, while Barrymore was in Poison Ivy.
In the first episode when Bob Armstrong (Dallas Roberts) and Coralee Armstrong (Alyssa Milano) were talking at the Spa, Coralee is reading a magazine that appears a poster from the show Pretty Little Liars and one of the directors Eloide Keene directed three episodes of that show