After being abducted by Katarina Rostova, Reddington finds himself alone in hostile territory unsure of who, if anyone, he can trust; with few leads to go on, Liz and the Task Force venture into unknown danger as they race to find him.
Liz, Dembe and the Task Force continue to search for Red, who attempts to escape his abductors with help from a surprise ally, but discovers he is not Katarina Rostova's only target in her hunt for information.
Aram goes undercover to infiltrate a secret society of wealthy thrill-seekers whose entertainment hinges upon spectacular acts of violence. Red tries to negotiate with a former associate involved in the Townsend Directive.
Liz and the Task Force investigate an infamous assassin who has a long history of weaponizing diseases, but has now turned to even more insidious activities. Meanwhile, Red and Dembe travel to Cuba in search of a lead, and Aram considers a new relationship.