After the ghost of Michael's ex-wife visits him from the afterlife and asks him to help continue running her low income clinic, he finds himself rushing back and forth between taking care of his own patients at Holt Neuro and her less fortunate patients at the clinic.
While interviewing doctors to run the clinic, Michael helps a man who passed out, but refuses care due to lack of insurance. Meanwhile, as Michael evaluates a woman, he notices lesions on her brain that require immediate surgery, even as he doesn't know the exact diagnosis.
Michael must decide if it is worth risking his practice to save a patient's life. Meanwhile, he courts Evan "E-Mo" Morris, a neuropsychiatrist to join his practice after E-Mo determines a patient's diagnosis by reading her body language.
While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.
When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.
Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.
When a spoiled pop star comes to Holt Neuro experiencing unusual symptoms, and a young girl at the Clinica exhibits similar symptoms on the same day, it forces both teams of doctors to try and piece together their common link.
When Michael's high school sweetheart comes to Holt Neuro with an irreversible condition, he will stop at nothing to try and save her, until Anna intervenes. Meanwhile, Zeke deals with the news that his best friend's cancer has returned.