Just before running out of gas, Karla rams the driver side door of the black Volvo, causing clearly visible damage. After cutting to a shot of her empty fuel gauge, the scene cuts back to a flash of the Volvo with an undamaged door.
Right after the black Volvo runs over the blonde woman, it is shown that another car hits the red minivan and the driver airbag gets blown out, rescuing the mother. Seconds later when the mother continuing the chase the airbags disappears.
Early in the film, Halle Berry drives a older model (roughly 2004) Chrysler Town and Country, distinguishable by the trim piece on the front grill. In the early scenes (for example at 10:13, the top part of that chrome-looking trim dips down in the center to accommodate a Chrysler logo. In virtually if not all of the chase/wreck scenes, that grill doesn't have that dip in the top center, indicating it's a newer model - but not much newer.
A 911 call is placed from a landline cordless phone, the phone number is associated with an stationary address. They know where the house is based on this phone number, the house doesn't move. The cordless phone has a range of maybe 50 ft. But the 911 dispatcher states, we will triangulate on your location, despite Halle knows the address where shes at. They only need to triangulate on cell phones which are mobile, using 3 cell towers to find their location.
One of only two states that are not divided into counties, Louisiana is made up of parishes (functionally identical to other states' counties). For the most part, this film gets this fact correct, i.e. the numerous references to Jefferson Parish. However, during the final scene of the film, one of the police cars is clearly and inappropriately marked "County Sheriff".
In the model of Chrysler Town & Country minivan that Karla is driving it shows her releasing the parking brake by hand when she has the kidnapper body-locked in the side door. This model of vehicle does not have a hand brake, it has a foot brake which can only be engaged on or off by the pedal left of the gas and brake pedal in the driver's floorboard. Her releasing the brake by hand in this vehicle is impossible.
In a fight scene, Karla easily grabs and holds onto the barrel of a shotgun moments after it was fired by Terry. However, metal barrels of firearms heat up greatly after being discharged, so grabbing it would burn Karla's hands.
Karla drove what appears to be an early-2010s model Chrysler Town and Country minivan while the antagonists drove a mid-1980s Ford Mustang GT. During chases, the film implies the Mustang is faster although in reality both cars have about the same performance, and given its age and apparent mediocre maintenance, the minivan likely accelerates considerably faster.
During the climax, the kidnappers' attack dog - who was moments ago on the dock just above the characters, hunting them - disappears without explanation and is never seen or mentioned again. However, the movie blatantly shows the dog getting shot by the big woman as she falls into the water.
After Karla's minivan deploys the front airbags in the accident with the black Volvo, shielding a pedestrian from being hit, she restarts the vehicle and continued the chase. Vehicles have a built in fail-safe that renders them unable to restart after an airbag deploys.
When Karla rings the police from the kidnappers house they say the response time is between 7 and 15 minutes. When Karla dispatches the last of the kidnappers all the police arrive at the same time. Many cars and 1 helicopter. The helicopter should have gotten there much sooner.
The goof item below may give away important plot points.
Toward the end of the film, the male kidnapper drives two miles to his house to drop off Frankie, then returns to kill Karla. All this happens in the space of less than a minute. This is not nearly enough time for all that to happen.