When emergencies occur, the trauma team from San Francisco City Hospital is first on the scene, traveling by land, by sea or by air to reach their victims in time. From the heights of the city's Transamerica Pyramid to the depths of the San Francisco Bay, these heroes must face the most extreme conditions to save lives -- and give meaning to their own existence in the process. In this initial installment, tragedy hits close to home, and the lives and paths of the team are forever changed.
Boone's marital problems take a back seat to a mad gunman who goes on a shooting rampage inside an office building. The incident forces Rabbit and Nancy to work together for the first time in over a year to treat the injured hostages. Meanwhile, Marisa realizes she's more like Rabbit than she would care to admit.
Tyler and Boone respond to an explosion at a Chinese restaurant and find that there is more to the situation than meets the eye. Meanwhile, Nancy's advanced medical training is put to the test. Elsewhere, Rabbit has an unexpected reaction to a bumpy flight.
A wedding celebration at sea is interrupted by a high-speed boat collision. As the team quickly rushes to their aid to treat the victims, things get lost in translation. Meanwhile, Nancy takes time to reconnect with her family. Elsewhere, Marisa comes to the aid of those close to her heart.
As a bad batch of heroin hits the streets of San Francisco, Glenn questions Nancy's judgment during an encounter with a "frequent flyer." Meanwhile, a bizarre theft sends Marisa on wild goose chase. Elsewhere, Boone contemplates his future and takes a new step, while a romance begins to take off.
Nancy and Glenn get caught in the crossfire as a sniper takes San Francisco hostage. Rabbit and Marisa are torn between instinct and protocol as each emergency medical call could be a trap. Meanwhile, Boone must learn to adapt to Tyler's new paramedic status and medical knowledge.
Nancy (Anastasia Griffith) comes under fire for ignoring protocol when treating a high school cheerleader and her actions put Dr. Joe (Jamey Sheridan) in the hot seat and their relationship on the line. Meanwhile, Rabbit (Cliff Curtis) and Marisa (Aimee Garcia) are quarantined after being exposed to a patient with meningitis. Elsewhere, a misunderstanding puts Boone's (Derek Luke) partnership with Tyler (Kevin Rankin) to the test.
Nancy and her father clash over his new role as the head of the Trauma center. Marisa has a surprising dream about Rabbit, and it begins to affect their working relationship. Boone and Tyler respond to a call at a mosque and have a difference of opinion on how to treat the patient. Elsewhere, Ira, known for his tendency to call in repeatedly for medical assistance, resurfaces.
In the process of gathering stories for his book, Glenn finds himself discussing unusual calls with his work mates and ends up hearing much more than he imagined. Elsewhere, Tyler's dad comes to town for a visit.
A problem with dispatch creates chaos when medics are sent scrambling to the wrong locations. Marisa reconnects with her army buddy Casey but their visit takes a dark turn. Boone plans a surprise party for Tyler's birthday. Elsewhere, Nancy, who has a lot on her plate as she deals with a terminal cancer patient, ponders the next step with Rabbit in their relationship.