As Joyce's sickness makes her begin doing odd things, a demon emerges from a meteorite and begins killing the mentally ill.
While Buffy and Dawn stay with Joyce in the hospital, Giles, Willow and Xander patrol the cemetery chasing vampires. Later, while watching the stars, Tara and Willow see a meteor crashing nearby Sunnydale. The Scooby group realizes that a demon called Queller has just landed on Earth. Joyce returns home since her surgery will occur only two days after, and the Queller arrives in the hospital attacking crazy people. Due to the compression of the tumor to her brain, Joyce acts strange having hallucinations, but she also sees the truth about Dawn and makes Buffy promise that she will take care of Dawn if she dies in the surgery. When the Queller arrives at Joyce's home chasing her, Buffy fights with it to save Joyce and Dawn.
- The Summers women are at the hospital when the doctor informs Joyce she'll have surgery in two days. The rest of the gang does their best to patrol and rid Sunnydale of a few more un-dead residents, emphatic that they will not bother Buffy while she is dealing with her mom's health. Meanwhile, Riley allows another female vampire to feed from him; he does not stake this one. The next day, Willow brings gifts to Joyce, Buffy, and Dawn in hopes of cheering them up. She brings Joyce a beer helmet, Dawn a book on the history of spells, and Buffy a history book and a yo-yo. With the brain tumor, Joyce has unusual outbursts, and the girls decide to let Joyce rest. On the way out, a mental patient sees Dawn and insists that there is nothing inside her.
Willow and Tara camp out on the roof of a building and watch the stars. Willow points out constellations to Tara, who points out several that she has made up. They cuddle and invent new star constellations when they see a large object streaking through the sky and crashing down in Sunnydale. They investigate the crash site and decide to contact the other Scoobies. The crazy man that spoke to Dawn, who has been released from the hospital, is walking through the forest when a creature attacks him and kills him.
At the hospital, the creature climbs along the ceiling, undetected. Buffy and Joyce talk the doctor into letting a highly agitated Joyce go home until her operation much to the non-recommendation of the doctor who enlightens Buffy that she will probably not get much sleep taking care of her mother. Buffy informs him that she isnt much of a sleeper anyway.
The gang finds the location of the crash and a hollowed-out shell, which was apparently used as a vehicle by a creature from space. They spread out the search and find the dead body of the mental patient. The Scooby Gang leaves to do research, and Riley stays behind to investigate the scene. He calls Graham for military reinforcements, and advises the soldiers how to deal with the situation when they arrive. They decide to try and track the creature from its residues of trace radiation.
At the hospital, a mental patient is attacked by the demon. Buffy's mom continues to act strangely and say things she doesn't mean to say. Dawn is hurt when Joyce calls her a "thing", but Buffy comforts her and tells her to ignore the things that people say when they are crazy. She tries to explain that when people are crazy, they think that nothing except themselves are real.
Through research, the gang finds that the creature is a Queller demon, and that it is periodically summoned to rid the world of plagues of crazy people. At the Summers' home, Buffy and Dawn put their mother, whose mental clarity continues to deteriorate, to bed. Dawn listens from her bedroom as Joyce babbles loudly. At first, she appears to be talking to the ceiling; however, it is soon revealed that she is talking to the Queller demon, which is watching her from the ceiling. Dawn tries to ignore the babble, and Buffy, who is downstairs washing dishes, turns on loud music and begins to sob. In Joyce's room, the demon falls from the ceiling and spits a thick layer of slime onto Joyce's face. Dawn hears the commotion and runs to check on her mother. When she sees the demon attacking her mother, she comes to the rescue, knocking it onto the floor with a coat rack. It flees from the room, and Dawn slams all the doors and screams for Buffy. Buffy runs upstairs to check on her mother and sister. They tell her about the demon, and she chases it downstairs where she finds Spike coming out of her basement. He asks her if she heard a noise, and she notices that he has been stealing pictures of her, but the demon attacks before she has a chance to berate him. Together, they fight off the demon, and Buffy ultimately kills it with a butcher knife while wrestling with it on the floor. Spike walks over and offers his hand to help her up. He pulls her to her feet, and their hands remain connected as Riley bursts through the door with the soldiers. Spike informed Riley that he had missed quite a show, making sure that Riley understood that Spike had been there to help.
Back at the hospital, Ben gets into his car to find that Dreg, Glory's demon minion, is waiting in the backseat. Although in subsequent episodes presented as a sympathetic character (his actions in this episode never again being mentioned) Ben reveals that he is the one who summoned the Queller, intending to handle the town's expanding mentally ill population via systematic targeting and extermination of the marginalized social group. Controversially, the script presents this like a minor point; Ben describes his actions testily as "having to clean up Glory's mess," which he revealingly complains that he has "had to do" for his entire life: the mentally ill being "Glory's mess" because her "brain sucking" has driven their numbers past what Ben's hospital is equipped to handle.
Meanwhile Joyce, because of her brief experience as an insane person, has realized the truth about Dawn, which Buffy confirms for her. Joyce insists that Dawn is nevertheless her daughter and urges Buffy to take care of Dawn in case anything goes wrong during the operation. While her daughters and the rest of the Scooby Gang watch on, Joyce is wheeled off to surgery.