On their way to a tropical vacation, CatDog get stranded on the median of a busy highway. Cat saves Lube the Greaser Dog from a tick, so Lube pledges his allegiance to Cat and vows to protect him from all harm.
Cat begins to work out furiously in order to stand up to the Greaser Dogs, who have stolen CatDog's frisbee. Dog becomes attached to a small toy cat he has purchased and decides to name it "Little Cat".
When Dog disobeys the community swimming pool rules, he (and Cat) are arrested by hard-core lifeguard Rancid Rabbit and sentenced to jail time. Their hard labor takes place at the pool, which shuts down for the winter and becomes a maximum security prison. Dog's insubordination gets him (and Cat) thrown in the "hotbox" (the sauna) for an arbitrarily long time. Cat is outraged at Rancid Rabbit's senseless cruelty and plans a prison break. He and Dog slip through the drain of the pool to freedom.Cat becomes consumed with collecting Mean Bob action figures. As his ...
Is this the end of CatDog? Fed up with being a two-headed freak, Cat elects to have surgery to separate himself from Dog. CatDog once again run for their lives from the Greaser Dogs to the "safety" of their house.
Cat chides Dog for being afraid of a horror film, but begins to get scared himself when he sees signs of the movie monster around the house. Tired of not getting his way, Cat hires a Pig to "join" CatDog in an attempt to out-vote Dog.
Strange neighbors suddenly appear across the street and Dog, obsessed with sci-fi comic books, thinks that they are aliens from outer space. After staying up all night, Dog is sound asleep on the day CatDog are to be interviewed for a TV show.
Cat pulls out a dusty tome, "Cats Through History" in order to teach Dog about feline royal treatment in Egypt. Winslow catches Cat in the act of reading Dog's diary and blackmails him into becoming his personal slave.
CatDog go on a mission to find pesky Gopher, who has ruined Cat's vegetable garden, and stolen Dog's bones from his bone cellar. Dog's up to his old tricks again, this time chasing a landing airplane all the way to the airport.
Cat tries out for the musical theater production of "Abe Lincoln: Superstar!" but is dismayed when Dog inadvertently gets the lead role. Dog discovers that another canine has tresspassed upon his favorite fire hydrant.