The Brain's voice is based upon that of Orson Welles. The voice actor portraying Brain is Maurice LaMarche, who also portrayed Orson Welles by dubbing Vincent D'Onofrio's role as Orson Welles in the movie Ed Wood (1994).
Originated as a series of segments on Animaniacs (1993) before being spun-off to its own show. It was moved to the WB's primetime line-up, where it won an Emmy. Then it was moved back to the Kids WB line-up, where it was Pinky, Elmyra & the Brain (1998) adding the familiar human character from Tiny Toon Adventures (1990). After a few episodes, it was cancelled.
Series Producer Peter Hastings described the show as "a two hundred fifty thousand dollar inside joke on Orson Welles". The Brain was inspired by Welles, and frequently slips in tributes to Welles' work into his schemes.
A bootleg tape of a short-tempered (and foul-mouthed) Orson Welles arguing with a recording engineer during a voice-over session has been widely distributed. It was used as the basis for an episode of this show, with The Brain reading cleaned-up versions of Welles' rantings. The episode's title, "Yes, Always", is taken from one of Orson's complaints.