The new owner of Shiloh quickly finds his hotheaded grandson accused of cattle rustling. He learns his neighbor is the widow of a friend who died with him. The sullied family name reduces their finance options putting Shiloh in jeopardy.
The Virginian counted 50 cows that were delivered to Grainger but the next morning five of them are missing. The Virginian feeling responsible tracks the stolen cattle down but finds himself arrested on murder charges and can't explain it.
A white girl is caught with her adoptive Arapaho parents stealing Shiloh cattle. She stays at Shiloh while the authorities try to find her white parents. She wants to return to the Arapaho but is forced to learn to live in the white world.
After helping deliver a herd of horses, Trampas decides to take a few days to visit an old friend nearby but he arrives in time for his friend's funeral. He is bothered by the circumstances of his death, so he decides to investigate.
Jake who can't hear or speak runs after he accidentally kills a man in a bar. He lands at Shiloh where his hard work results in a job. Stacey seeing Jake can't express himself decides to teach him to read and write but puts him in danger.
After a stagecoach holdup and accident, Trampas stumbles into a farm with a concussion and amnesia. The farmer and his two kids tend to Trampas but the white handled gun he is carrying puts him into danger from the law and the outlaws.
A man wanted for murder and robbery escapes jail and ends up in Medicine Bow where he befriends Stacey in a fight. He goes to work at Shiloh as a ranch hand and Elizabeth takes an interest in him. However, Stacey is less certain about him.
Trampas leads a two man posse to capture the brother-in-law of a friend in jail who is innocent when the Sheriff is injured. They encounter others who hinder their progress and an unhappy couple. But the big problem is Trampas' partner.
A woman visits her sister in Medicine Bow bringing her teenage daughter who is enamored with a Dead Eye Dick western novel. She develops a crush on The Virginian after he settles her horse aggravating a teenage boy she meets who likes her.
When a friend of The Virginian is killed and the posse won't follow the killer out of the county, The Virginian goes alone. He tracks the killer and a woman involved to a remote outlaw controlled town but can he get them back to the law?
A wild white stallion draws the attention of Elizabeth who convinces her grandfather to buy it. Against his wishes, she tames and breaks the stallion when Trampas is unable to. Her and the stallion become inseparable but a problem occurs.
Upon returning from Texas The Virginian finds himself in the middle of express line holdup. On the stagecoach he meets a beautiful woman who ultimately confides in him that she is a courier carrying a package - possibly illegal.
Jim Boyer Sr. returns to his wife and son living in Medicine Bow and takes a job at Shiloh. Boyer is a very capable but ignores detail in his work as he tries to earn the foreman job at another ranch Grainger is hoping to purchase.
Howie is leaving his free life on the range to marry the beautiful Donna whose father is a leading businessman. Once married, they move into a new saddle shop Howie starts. He finds the life confining and gambles away the payment on it.
Stacey is forced to kill a man who tries to rob him. He returns the body to the man's sister who asks Stacey to leave rather than see the Sheriff. She is afraid their younger brother who joins the Shiloh cattle drive will try for revenge.
Sue Ann leads a dull life as the daughter of a homesteader taking care of her father, two young brothers, and their hired hand Joe who would like to marry her. However, she leaves home to see San Francisco but where will she get the money?
Stacey buys a gold watch that may have belonged to his dead dad. It sets him off on a journey to find the truth about his parent's deaths. He meets an orphaned girl who owned the watch and is curious about her parents who she never knew.
The Virginian looks for Stacey in a town where they are to finish up a cattle deal. His search results in finding Stacey in jail found guilty of murder. He is to hang the next morning forcing The Virginian to find the real killer fast.
After holding up the bank, Dell Stetler and his partner hold the Graingers hostage at Shiloh to help their wounded comrade. John is forced to bring the doctor to Shiloh to tend to the man as he and Stacey plot a way to free themselves.
The Virginian is shot crossing a large Texas ranch. The owner taking him in tries to hire him to be his own foreman. The owner likes to make his own rules putting him at odds with his wife over their son and the running of a gauntlet.
Stacey has developed an interest in a girl but her father doesn't approve of him. After dragging Stacey, the father is found shot in the back. When the $300 he was carrying is found in Stacey's saddle bags, Stacey is charged with murder.
An old and successful friend and his daughter from Chicago visit the Graingers. John is surprised when he learns they want to stay in the area. The high society daughter falls in love with Trampas who doesn't know about her secret illness.
Dr. Spaulding decides to hire another doctor to help share the load but he is unsure whether the attractive female doctor he is sent will work out. The Virginian takes a strong interest in her and her problems as she tries to adapt.
Stacey is shanghaied in Medicine Bow to take the place of a cavalry recruit. An inept officer allows two sergeants to keep up the facade that Stacey is a recruit while putting him through inhumane conditions to keep him quiet.
The Virginian travels to Winton to buys oats for Shiloh. He finds himself in the middle of a fight between the farmers and ranchers with the owner of the oats at the core of the fight with a rancher who is a close friend of John Grainger.
Trampas goes to visit Ida Martin and son Joe who he lived with as a child. Having not seen them in a few years he finds their place deserted. When he learns Joe was killed by a posse, he can't believe the reason given for his death.
Trampas tries to make friends with a beautiful girl he spots riding a pinto but she avoids him. Once he learns who she is, he asks her to a dance but her and her family are hesitant. Eventually she agrees to go but old issues haunt her.
John Grainger asks an old friend from Maryland to come to Shiloh to take the rough edges off his grandkids. She does as he asks quite well but is less than popular with the kids and The Virginian. Unknown to them, she has a secret plan.
A nurse comes to Medicine Bow so see if an outlaw Ryker captured might be her brother as they were both orphaned at an early age. When he escapes and is shot, he uses her feelings to get help as Ryker who is attracted to her pursues him.