Slim and Jess help a family group of entertainers from Japan traveling east when their wagon breaks down. They have found a boy Mike whose parents were killed my Indians. A trio of men are following the troupe thinking they have opium.
Slim and Jess need to present a good image to a visiting judge to keep Mike. However, when a saloon girl looking for a job, a woman who has been conned, a bounty hunter, and a doctor who is really an outlaw appear it doesn't look good.
Daisy escorts Jess to Cheyenne for a bad tooth where Jess catches a member of a gang who robbed the Laramie bank. Jess is asked to escort him to Laramie for trial but the rest of the gang is after him as he had the money and hid it.
John Sanford, a mountain man, along with his sons wants revenge for the killing of his son. The man convicted is going to prison but they decide to capture him at the Sherman Relay Station and lynch him from the nearest cottonwood tree.
Jess is riding shotgun on a stage that was wrecked by two men to steal a $20,000 payroll. He rides after the men chasing them to Montana where he learns one of them is a close friend he helped but there are unexpected dangers.
A felon who framed Slim rides in with a wounded marshal after fives years in prison. Slim doesn't trust him but the marshal wants Slim to go with the felon to return the $20,000 he stole but there are issues including his step-daughter.
Jess due to a lame horse is forced to stop over at the Tolliver place which used to be a relay station at the same time the Dyer gang is in the area after a bank holdup. They are to meet someone there resulting in Jess being a hostage.
While staying at the Laramie hotel, Mrs. Cooper sees a man leave the room of a murdered woman. Due to a mix-up at the sheriff's office the wrong man is identified by her. The correct man is Slim's boss causing pain for everyone.
Jess rescues a crippled Blackfoot boy from a scalp hunter. Several of the Blackfoot have escaped the reservation with the Army rounding up most of them. With tensions high Mike and the boy leave putting both into danger from both sides.
Slim is a civilian scout for an Army officer who blames Slim for his ordering his men to massacre a Sioux village although Slim was not at fault. The tribes threaten war if the officer is not punished when he escapes to continue the fight.
Jess is acting deputy when he catches a man breaking into the sheriff's office. He is a released felon who was a gunfighter that says he was framed for a robbery by Sheriff Mort Cory who is out of town. He wants revenge for being framed.
Gil Martin is accused of murder in Cheyenne, but he's innocent. He was released from prison on parole. His girlfriend is killed by a controlling marshal. He comes to see Slim who had offered a job, but Slim wants him to turn himself in.
Jess is framed for a murder after threatening a rancher who reneged on the sale of horses. Fearing he is going to be lynched, Jess escapes a posse only to land in an isolated outlaw hideout with outlaws he must join to stay alive.
After saving the life of an Arapaho girl in a fire and helping acquit her in a trial for killing a man, Slim finds her his possession due to Arapaho law. When she won't leave him, he takes her in but soon finds he has feelings for her.
When Jess' horse is stolen, he tracks it and the thief, a young Mexican boy, to a town. The sheriff arrests the boy and Jess is forced to stay to testify only to learn the Judge is vindictive due to the murder of his son by a Mexican.
Slim is working as a range detective looking into cattle rustling after his ranch was hit. He finds out who may be doing the rustling. He catches one of them, a pretty girl, but not before she wounds him putting him in mortal danger.
Illiterate teenager Billy is caught between two drifters who want him to aid them in crime and Daisy along with Slim and reluctant Jess who try to teach and reform him. His only relative is a crusty uncle who wants nothing to do with him.
The husband of Slim's neighbor returns saying he has reformed and has a bank draft he wants to deposit but three men are chasing him for it. After saving Jess' life while working on a stage, they decide to help him but is all as it seems.
While looking for mustangs, Slim finds a small but somewhat tame one for Mike. That night someone steals the horse. Slim tracks it to a girl who owned the horse but also the middle of a potential range war between two groups over land.
Jess returning from a cattle sale helps a stranger caught in a gun battle who later trades identities with Jess when he is nearly killed in a saloon. Jess recovers but is mistaken for the stranger who is an outlaw but no one believes him.
Slim is acting sheriff when his neighbor's three outlaw step-brothers return looking for a place to rest and collect funds for their planned escape to Canada. Using his wife as a hostage they force him to help them with their plans.
Jess is in charge of a stage taking $50,000 from Laramie to Denver. A couple of outlaws develop a novel way of robbing the stage by blowing it up. Jess must track one of the outlaws who is wounded with the money to a strange setting.
Slim and Jess decide to go with Glen Colton to track a stage carrying his fiancé after the Sioux attack the relay station and go on the warpath. In their encounters Colton is never killed but almost captured raising questions with them.
Slim can provide an alibi for a man on trial for murder but when he returns at the request of the daughter to testify, they find him already hung. After being shot at he returns to find the daughter arrested for the murder of a witness.
Old memories surface when the officer in charge of Jess' POW camp turns up as the new deputy in Laramie. He tries to overcome the issue until other POWs arrive with revenge on their mind resulting in Slim and Jess against each other.
Old feelings revive when a woman Slim wanted to marry once returns to Laramie. She is there to sing in the casino her boyfriend is reopening after finishing a trip to prison. Her, her boyfriend and Sheriff Cory all have plans for Slim.
Jess finds himself in the middle of a potential marriage when he goes to help an older neighbor fight a range fire. He is asked to pick up the man's intended bride in Laramie but he soon determines she is not who she says she is.
Slim along with Daisy and Mike try to help a girl rescue her mother from a well when the woman's husband and two partners arrive. They have robbed the stage. The partners want to leave but Slim tosses the money in with the woman.