London 1891. Renowned explorer Sir Malcolm Murray and the strangely beautiful Vanessa Ives recruit American sharp-shooter Ethan Chandler and Dr. Victor Frankenstein to help them search for someone who has been lost.
Vanessa and Sir Malcolm encounter the mysteriously beautiful Dorian Gray at a party. Things take a turn, however, when renowned medium Madame Kali hosts a séance. Meanwhile, Ethan befriends Ms. Brona Croft, a young Irish immigrant.
A haunted Vanessa turns to Sir Malcolm for solace. Meanwhile, Dorian Gray meets an intriguing woman with a secret, Hecate hunts down a prize for her mother - and Ferdinand Lyle reveals the disturbing backstory of the Verbis Diablo.
Lyle reveals how the story of the Verbis Diablo affects Vanessa. Meanwhile, Hecate tries to get closer to Ethan; Angelique and Dorian's romance grows; and Inspector Rusk interviews the sole survivor of the Mariner's Inn massacre.
Vanessa, Ethan and Sir Malcolm protect the mansion from another attack. Meanwhile, Angelique is humiliated while out with Dorian and, as Evelyn works on a new totem, Hecate returns to her mother with a gift.
Sir Malcolm continues on his journey with the enigmatic Kaetenay. Meanwhile, Ethan gets some unexpected help from Hecate, Drs. Frankenstein and Jekyll hatch a plan and unbeknownst to her, evil forces track Vanessa's every move.
Vanessa contacts her old friend Ferdinand Lyle for help. Lyle introduces her to Catriona Hartdegen. Lily, Dorian and Justine put their plan in motion. Ethan, Sir Malcolm and Hecate arrive at Talbot's ranch.