Dr. Venture and family are in Mexico where the boys get kidnapped by the Monarch's Henchmen. Brock goes on a rampage to get them back and Dr. Venture loses both his kidneys and wakes up in a bathtub of ice.
Dubbed the Ninth Wonder of the World, Jonas Venture's space station, Gargantua 1, has developed a problem, and it's up to Dr. Thaddeus Venture to fix his father's creation. But could the station be haunted by vengeful ghost?
Brock goes on a wilderness retreat, and gets more than he bargained for when he encounters the Army searching for something. Meanwhile, the Venture family retreats to the panic room when the forces of both The Monarch and Baron Ünderbheit attack.
Dr. Venture takes the X1 to "Brisbyland" for a meeting with the theme park owner Roy Brisby. But the boys get kidnapped by the "Orange County Liberation Front" and Brock and his former lover and secret agent Molotov Cocktease mount a rescue.
The boys discover a dangerous pod in the lab that projects your fantasies, thus trapping you inside. Dr. Byron Orpheus is introduced as well as his daughter, Trianna, whom Dean becomes enamored with immediately.
Pete White, Master Billy Quizboy, and Dr. Venture are recruited by their old college professor, Dr. Richard Impossible, to work for him doing super-science at his remote arctic lab. But when Hank is infected by one of Dr. Impossible's old serums, Brock must race to locate the lab and save Hank's life.
To raise much-needed cash, Dr. Venture holds a yard sale for his father's old, unwanted super-science equipment and inventions. Brock and other agents from the Office of Secret Intelligence maintain security as many of Venture's arch-nemeses attend, but The Monarch has other plans.
Hank and Dean learn about Brock and Dr. Venture's early days as they attend a funeral for Mike Sorayama, an old college buddy they used to tease. But the funeral proves to be a ruse by Sorayama to exact revenge for their torment.
It's Christmas and the Ventures are having their annual party. But the festivities are interrupted by the Dean who accidentally summons a Christmas demon, and the Monarch who plans to blow up the Venture home.
Life goes on after the tragic deaths of Hank and Dean. Meanwhile, the Monarch deals with life "inside" but you can't keep a good criminal mastermind down. But will King Gorilla prove to be his greatest ally, or his worst betrayer?
The Monarch has escaped from prison, and the Henchmen re-assemble to serve him. Dr. Venture takes Dean to a shopping mall and the family gets ambushed by the Monarch who was there attempting to win back Dr. Girlfriend.
Molotov Cocktease fills in at the Venture compound as Brock goes on a mission to terminate a rogue agent. While Molotov tries to beat some masculinity into Dr. Venture and his sons, we learn something of Brock's past through flashbacks.
Team Venture find themselves trapped in the clutches of a bloodthirsty Egyptian cult and their time machine. Dr. Venture narrowly escapes and teams up with Master Billy Quizboy and Pete White, but promptly forgets to mount a rescue. So it's up to Brock and a pantheon of history's greatest men to find another way out.
While a mysterious extra-terrestrial Inquisitor evaluates human culture, Dr. Venture discovers an old video recording from his father informing him he must, before tomorrow night, locate and assemble the hidden pieces to a device that will save the Earth from certain doom.
Baron Underbheit returns as the Venture Bros jet crashes in Underland. The Baron seeks revenge on Dr. Venture and attempts to marry Dean, who is dressed in a Princess Leia slave girl costume when they are captured.
Gargantuan 1 crashes and Col. Bud Manstrong survives and hailed as a national hero. He and the Ventures are then honored at the White House. But the ghost of Abraham Lincoln appears suspecting an attempt will be made to assassinate the President.
While Dr. Venture constructs his Venturestien Monster, Brock has an existential crisis and a parody "Scooby Gang" arrives, looking to solve a "Mystery". Hilarity, violence, tripping on some vine juice, and a general pissing on Scooby Doo.
The Monarch proposes to Dr. Girlfriend. Thanks to the hasty actions of the Henchmen, the entire Venture family finds themselves participating in the wedding. Phantom Limb crashes the party, threatening to destroy everyone unless the wedding is called off.
At long last, The Venture Bros. peels away the onion-like shrouds of time for a look back into the troubled past of America's most beloved hydrocephalic former boy genius, to reveal dark secrets that even he didn't know about.
The Monarch attempts to strike Dr Venture where it hurts, by kidnapping Hank & Dean and holding them for a $10M ransom. The plan is foiled when rainbow hero Captain Sunshine arrives to rescues Hank, making him his new sidekick, Wonder Boy.
Henchman 21, determined to find out who murdered his friend, Henchman 24, kidnaps Hank and Dean and subjects them to the dreaded Chinese water torture. Meanwhile, the Monarch eats a fancy salad and has a reaction to one of the ingredients.
Hank and Dean finally graduate from their learning beds. But what's next? College? The army? Life on the outside sees the boys taking two very different career paths -- and one of them leads straight to the Phantom Limb.
Somebody has been kidnapping the world's super-scientists and super-villains. But whom? And to what end? The OSI, SPHINX, The Guild of Calamitous Intent and The Revenge Society must put aside their differences and convene a secret think tank to solve a mystery of epic proportions.
Dean's summer internship in New York City turns deadly when he learns his new employer harbors a dark secret. Meanwhile, Doc's newfound love of show tunes makes him an easy target for the newly re-formed Revenge Society.
Dr. Venture isn't feeling himself lately...he's killing himself. Orpheus suspects it's an inside job and pries the Venture family from their touch football game to help him teach Doc the value of self-love.
The men of Conjectural Technologies learn that success comes with a price when Billy is kidnapped by the mysterious and extra-creepy investors behind their recent windfall. But who is behind the investors? SPHINX would like to know.
See the Venture Family as you've never seen them before: in an 11 minute documentary-style animated UNCENSORED special. Follow the meteoric rise, the equally meteoric fall, and the decidedly un-meteor-like second coming of the most important band Hank Venture, Dermott Fictel and H.E.L.P.eR. robot have ever been in--Shallow Gravy. If you're hungry for rock, then open wide--because here comes a ladle of heavy metal fire and metaphoric meat drippings!
Dr. Venture hires an army of college interns to help with his ambitious new science project. Dean finds love among the new recruits, but class warfare and nuclear physics threaten to tear the Venture Compound apart. And if they don't, The Monarch will.
One of Dr. Venture's old inventions seems to have gotten a mind of its own, so General Manhowers sends him to Central America to fix it. The Ventures must all confront their own hearts of darkness if they're to survive what's waiting for them in the jungle.
Dr. Venture moderates the second annual Treaty of Tolerance Summit (at the old Venture compound) where the Guild of Calamitous Intent and the O.S.I. argue over new agreements. Meanwhile, both Dean and Hank go on side adventures around the compound.
Mrs. Monarch finds out from the Guild Council charter that they must either retire as villains, and commit one last arch each, or leave the Guild Council. Dr. Venture tries to get laid by a black widower.