Roger runs away after he and Stan have an argument. Once the CIA finds out, they organize a search team in order to find him and bring him in for questioning. So now Stan must either kill Roger or choose friendship over his career.
A man claiming to be Stan's real father shows up at his father's funeral. Stan explains that the man to whom everyone knew to be his father was in reality a stranger he met at a bus stop on his wedding day. So now Stan's real father, a secret agent, wants Stan to accompany him on a top secret mission. Unbeknownst to Stan, his father has a hidden agenda.
After embarrassing his boss at an award ceremony, Stan and his family are transfered to Saudi Arabia. At first hesitant, Stan quickly begins to enjoy the fascist ways of the country and even goes as far as getting a second wife after Francine refuses to do work until Stan asks for his old job back. While outside of the house, Steve learns that boys his age are considered men in the new country & Haley falls in love with a terrorist.
In order to gain entry in a women's social club known as the Ladybugs, Francine pretends she is cheating on Stan. After her fellow Ladybugs wish to meet her "boytoy", guilt stricken Francine confesses that she is not having an affair. Now she must either actually cheat on her husband or the Ladybugs will kill her in an attempt to keep their secrets safe.
Because of a past incident at his own prom, where he was lured into a dance with the homecoming queen only to have a pile of pigs dropped on him, Stan wants revenge by showing off that he married a homecoming queen, Francine.
Stan and Roger become best friends in Atlantic City, taking their friendship to a whole new, unexpected level, when Roger absorbs all of Stan's memories. Meanwhile, Hayley and Steve conspire to break up a good-looking couple so that they can date the two.
Roger finds another neighborhood kid to be his best friend, but winds up getting in an abusive relationship. Meanwhile, Stan and Francine become obsessed with saving Mr. Pibb after they find out that it is being discontinued.
Stan lies to his family and tells them they're the only survivors of a nuclear attack, instead of admitting that he fell for a CIA drill and losing their trust. Roger sets up a phony wedding so that he can register for a new blender.
Francine discovers that every one of their family vacations have been artificially experienced in tanks filled with green goo. This makes her very angry and she demands a real vacation. When they finally go on a real vacation Francine thinks this vacation must be fake too since it seems too good to be true. She therefore causes the family to suffer the consequences. Simultaneously, Roger attempts to become the greatest actor who ever lived.
Francine agrees to be the surrogate mother for their gay neighbors' child. But when the child is born, Stan kidnaps her and plans to take her to Nebraska, where he can legally keep the child away from them.
When Stan's mom gets dumped for the umpteenth time by a boyfriend, she comes running to Stan for support. Feeling threatened by her always-visiting mother-in-law, Francine is determined to cut StanÂ's umbilical cord and figure out what keeps going wrong with the men in her life.
After one of the wives of Stan's CIA coworkers tells Francine that her husband is missing, Francine tries to persuade Stan to be more open with her. He responds by telling her that he killed the husband.
With Francine gone to visit her parents, Roger holds a Spring Break blowout at the Smith house. During the festivities, Stan falls for a "Spring Break Buddy" and Steve is on the verge of losing his virginity.
Stan and Francine are upset when Steve reaches puberty. However, Francine wants him to stay young, and Stan wants him to skip puberty and go straight to 21. And both of them use top-secret CIA technology to make sure it happens.
When Stan becomes his boss's go-to guy, he feels like he can't say no to anything including outrageous personal requests. But when Francine gets roped into the annoying ordeal and her romantic Valentine's Day get-away is ruined, she lays down the law and forces Stan to say "NO".
When Stan finds out that Francine was engaged before they met to a man who disappeared in a plane crash but is still alive, he launches an elaborate plan to find out if she would choose the other man instead of him.
Steve gets revenge on the popular kids at his school after they smear his girlfriend who was running for class president. But he later learns that somebody else was responsible for the attacks, and the popular kids want revenge.
Steve has to wear a back brace because of his Scoliosis, but then finds out that Stan has been bald since college. Meanwhile, Roger, Francine, and Hayley go to a spa together even though they only have two free passes.
Stan's night out of fun with the guys from the agency snowballs into a kidnapping situation, and could possibly end in murder. Meanwhile, Roger doesn't realize that he's been invited to a fraternity "pig party."
When Hayley and Steve leave for their respective summers of fun, Francine looks forward to her newfound alone time with Stan. There's only one problem: Roger is still living in the attic fighting for every second of attention he can get. When Francine teaches Roger to be self-sufficient, he finally gets a place of his own. Stan fears that he will bore Francine into leaving him and cooks up a scheme to bring Roger back to the house and liven things up. Meanwhile at camp, Steve and his pals fall prey to a scheme that doesn't quite have the effect they were hoping for.
Francine lets herself go right before she and Stan renew their vows after she learns that Stan married her for her looks. Stan responds by having his retinas removed so that he doesn't have to look at her.
When Hayley rejects Stan's advice, he decides to start a dry-cleaning business run by a bunch of strippers. But when the business fails miserably, he is forced to become a male stripper to make some extra money.
The Smiths' savings are gone, so Stan selfishly takes out a second mortgage and buys a racehorse so that he can save his SUV. Meanwhile, Steve and his friends try to help an obese shut-in to make some money.
Stan gives Francine "love coupons" for Valentine's Day, but refuses to honor them once he becomes preoccupied with his very own CIA cyborg. Meanwhile, Roger helps Steve and his friends remake a classic '80s movie.
Stan discovers that Roger is one of his all-time heroes: a member of the 1980 U.S. Olympic Hockey Team. But when he also discovers that Roger used steroids, he turns to his other hero for advice on how to handle it.
Stan has a clone of Steve created so that he can have a competition with Francine to see who can raise him better. Meanwhile, Roger travels to Thailand to find Hayley and Jeff, and to get the reward money.
Stan's plan to out-do the neighbor's fancy haunted house backfires when Roger releases the serial killers he was borrowing from the CIA. Meanwhile, Steve faces Toshi's revenge when he takes a liking to his sister Akiko.
After all of Francine's repressed memories come back to her, she decides to be a stand-up comedienne and gets her own sitcom. Meanwhile, Steve finds a female companion for Klaus, but he quickly grows tired of her.
When Stan and Roger disagree over a recent string of events, Roger moves out of the house in protest but is quickly replaced by another warm body. After Roger learns of the replacement roomie, the two of them battle for Stan's affection. Meanwhile, Steve gets a new job at school that allows him to do a little self-promotion over the P.A. system.
In an attempt to advance in the CIA, Stan begins playing golf with Senator Buckingham. Things are going well until Roger accidentally sells the senator's daughter to a drug lord, forcing Stan must choose between family and his career.
When Steve has trouble crossing over into the "cool kids" social circle, Klaus and Roger place their bets to see how quickly Roger can make him cool. Everything they try backfires until Steve becomes the in-crowds designated driver. Meanwhile, Stan and Francine take turns pranking each other.
After Snot professes his love for Hayley and gets shot down, Steve and Roger devise a plan to cheer him up. Roger dresses up as Steve's cousin from New Jersey, Jenny Fromdabloc, and Snot falls hard for her. Meanwhile, Stan want to live like a gentleman of the 1960s, complete with dark suits and dry martinis.
Stan spends some quality father-son time with Steve at the local zoo, but things go horribly wrong when Steve slips into a gorilla exhibit. Meanwhile, Roger bets Hayley that he can become a great Country singer and sets out to write the most heartbreaking song of all time.
Stan convinces principal Lewis to get married so that he will get to be the best man, but his plan hits a snag when he invites principal Lewis's old cell mate to the wedding. Meanwhile, Roger goes to Miami to show off his new shorts.
A Langley Falls talk show outs Francine as "Baby Franny," the toddler who was once rescued from a well by a heroic fireman. Then, on the anniversary of her rescue, she falls down the well again and makes a shocking discovery. Meanwhile, Stan and Roger have an entrepreneurial "eureka!" moment when they think of the world's next game-changing business opportunity - male stripper shoes.
Steve is eager to prove that he's no longer a little boy, so he sets off to prove his manhood by joining Stan, Bullock, and the rest of the CIA on their annual hunting trip. Meanwhile, Roger and Klaus set off on a cross-country road trip.
In a desperate attempt to show Steve that she's still a "cool" mom, Francine teaches him a vast array of shoplifting techniques to try out at the local mall. But when their attempt to pull off the ultimate heist at "The Gash" goes awry, Steve is captured and sent to a Venezuelan sweatshop. Meanwhile, Roger, Hayley and Klaus form Langley Falls' first Russian Balalaika trio.
Stan drugs Steve and his friends and puts them in the CIA holodeck just to give them the outdoor experience, while Hayley makes herself Roger's queen after buying his home star on the International Star Registry.
Roger and Francine stumble upon another alien in the woods and Roger tries to romance her, but he soon becomes annoyed with her behavior and wants to call the CIA to have them take her away, but then he has a change of heart and decides not to.
Stan takes the family to church and Steve questions everything. Stan decides to help Steve develop some faith, but the plan backfires when Steve points out logical flaws with faith and religion. Stan spirals into a deep depression where he attempts to find pleasure and meaning in life, but finds none. When Stan almost drowns in a pool he has a vision of God. Stan believes that he is the new Noah and that he must get his family to an ark in order to survive the flood.
Stan is afraid that Hayley is drifting aimlessly through life, so he tries to teach her the value of a good plan. Stan takes Hayley on a CIA mission, but the mission backfires when Bullock fails to develop a good plan. Hayley discovers that Bullock is sleep-deprived which is leading him to plan dangerous missions. In order to save Stan, Hayley must teach him how to improvise. Meanwhile, Jeff tries to recreate a musical instrument he saw in a dream.
When Francine finds out that Stan is involved with slot car racing, she becomes less attracted to him. Meanwhile Roger becomes a stewardess and performs comedy routines on planes and gets mad when people find the other stewardess funnier.
Klaus gets transferred into the navigation system of Stan's car after Stan refuses to pay for a life-saving surgery. Steve and his friends prank Roger's Frank character and he terrorizes them for revenge.
Steve and Snot go to summer camp, but each wants something different out of the experience. Meanwhile, Roger organizes a "Burning Man" in the Smith's backyard for the anniversary of Hayley and Jeff. Stan and Francine get caught up in the celebration.
The family gathers to hear the results of Stan's annual physical. The doctor reveals that Stan is not taking care of himself and orders him to live a healthier life. Stan is stubborn, so Roger and Francine conspire to scare Stan with a near death experience. Stan becomes addicted to the near death experience when he watches his life flash before his eyes. Meanwhile, Klaus takes Steve on a tour of a university.
The Smith family is participating in televised race that takes them all over the globe. Stan and Hayley are frustrated that their teammates don't take the race seriously. Steve and Francine try to turn the race into a vacation, while Roger abandons the race to enjoy karaoke. Stan and Hayley abandon their teams and attempt to complete the race on their own. Meanwhile, Klaus watches the race as it unfolds on television.
Francine dreams of having a larger family and wonders if being adopted has affected her view of families. Hayley encourages Francine to track down her birth parents. Francine finds her family and attends a family reunion. At the union, the family patron decides to whittle his large family down by trapping them on the property and forcing them to fight each other. Meanwhile, Stan becomes obsessed with the TV show "American Pickers".
Roger is lonely and unhappy as he thinks everyone but him has a stable relationship. Roger tries online dating and ends up on a date with Klaus, who is also looking for love. Klaus and Roger begin a passionate and secret affair, but Roger wants a more serious commitment. Meanwhile, Steve tries to get out of taking the Presidential Fitness Test.
The Smith family receives a notice that Grandpa Jack's storage unit is being auctioned away. Stan forbids the family from visiting the storage unit but Steve wants to learn more about Grandpa. Steve discovers a garbage truck in the unit and brings it to Stan. Stan has a few good memories of the truck so he and Steve start running the old garbage route. Steve learns that the truck was part of a drug running business but hides this from Stan. Meanwhile, Roger takes Hayley on the competitive bumper pool circuit.
When Steve starts acting out his sexual energy, Francine asks Stan to give him the talk, but he makes Steve join a creepy father-daughter celibacy club with him instead. Also, the family builds a water slide in the backyard.
Traumatized by [link=tt0857332], Roger becomes concerned about outliving the family, so he fakes his death, spoofs [link=tt0103524] and traps the family in the game. Klaus opens a convenience store but becomes paranoid about shoplifters.
Steve gets competitive and turns on his best friend during the father-son events at Possum Lake, the home of the legendary fish-monster called Old Ulysses. Roger pretends to be the local tour guide and becomes more infamous than the fish.
After a fight with his dad, Steve goes to an all-girls boarding school. Roger realizes that Steve has become stuck in his own zany spinoff sitcom. Meanwhile, Stan is annoyed by Steve's British replacement.