When I was vacationing in America, I had the chance of seeing The Venture Bros. on Adult Swim. After watching only one episode I already decided to buy the DVD. I've been in love with the series ever since.
The humor is everywhere. It's in the dialogue, it's in the story, it's in the characters. The show contains many and many parodies of movies, comics and other cartoons. Sometimes there are even straight rips. And yet, The Venture Bros. cartoon manages to stay unique and original.
I recommend this to everyone.