Rebecca Front, Cressida Bonas, Richard McCabe and Phoebe Nicholls also form part of the cast of Doctor Thorne.
The three-part series centres on the titular Dr Thomas Thorne (Hollander), who lives with his penniless niece Mary (Stefanie Martini).
When Lady Arabella Gresham (Front) finds out that her son Frank (Harry Richardson) is in love with Mary, she is horrified and believes it is his duty to make a rich marriage to save their family estate - after her husband Francis Gresham Senior (McCabe) has frittered away their fortune.
Scheming with her sister-in-law (Nicholls) and niece (Kate O'Flynn), Arabella targets wealthy American heiress Martha Dunstable (Brie).
McShane is playing alcoholic railway millionaire Sir Roger Scatcherd, while Bonas will portray Mary's friend and confidante Patience Oriel.
Gwyneth Keyworth, Danny Kirane, Janine Duvitski and Tom Bell will also feature,