Vanished centers around the sudden disappearance of Sara Collins (Joanne Kelly), a teacher and the wife of Senator Jeffery Collins (John Allen Nelson). Once the FBI gets involved, the secrets of Sara and those around her start to come spewing out and many have possible motives including her husband's political enemies, son Max (John Patrick Amedori), and daughter Marcy (Margarita Levieva).
FBI Agents Graham Kelton (Gale Harold) and Lin Mei (Ming-Na) lead the investigation of Sara's disappearance. Before Kelton can tell what he's uncovered, he's murdered and Agent Daniel Lucas (Eddie Cibrian), takes over the case. Other performers in the series include Rebecca Gayheart, Christopher Egan, Esai Morales, Leslie Odom Jr., Penelope Ann Miller, Joseph C. Phillips, Jeff Michael, Christopher Cousins, Josh Hopkins,