Jackson Oz and Abraham Kenyatta fly to Japan to recover the rest of Oz's father's research involving animals. Also, Jamie convinces Mitch to accompany her on a trip to her hometown in Louisiana to show a senator their findings on the abnormal behavior of the zoo lions. In Paris, Chloe is the first to be recruited by a shadowy intelligence agent, Gaspard Alves (Henri Lubatti), who is looking for the cause of the strange animal behavior, and a death row inmate escapes from a Mississippi prison after a vicious wolf invasion sets the prison ablaze.
Jackson, Jamie and Agent Shaffer search for a chemist in Alabama who has evidence of Reiden Global's role in the growing animal problem. Meanwhile, Chloe, Mitch and Abraham fly to Rio de Janeiro to delay the local government's plan for a massive bat extermination and come up against a ruthless drug lord.
Mitch escapes from Reiden with the mother cell and rejoins the others. The team digs into Delavenne's dealings with Reiden after he's seen by Mitch at the company's headquarters. Mistrust builds between Mitch and the others when they learn he was trying to return the mother cell to Reiden in exchange for his daughter's medicine.
Chloe tries to bring light to the rising threat from the animals. Jackson is taken to a hospital and while they are there Mitch works to create a cure. However, there are many obstacles they must overcome.