The show began on radio in 1949 and was then produced for television by Eugene B. Rodney and star Robert Young. The show ran for 6 years, eventually airing original episodes on NBC and CBS. Both CBS and later, ABC continued to air reruns as late as 1967.
Series star Lauren Chapin, who played the youngest daughter Kathy said she found out the show was canceled for good when she reported to work and the guard would not let her into the studio.
The show took place in the town of Springfield. Even though they never specified the exact state in which the town was located, several times, characters mentioned Altoona, an actual city in Pennsylvania.
The character 'Jim Anderson' was ranked #6 in TV Guide's list of the "50 Greatest TV Dads of All Time" (20 June 2004 issue).
The NBC radio series on which the show was based had Jim being somewhat clumsy and slow-witted, often getting himself into embarrassing scrapes. On the TV version he's a lot wiser and makes far, far fewer mistakes.
When the sitcom first aired in 1949 on NBC radio at 8:30 p.m. on Thursdays, it was sponsored by Maxwell House. When the series moved from NBC radio to CBS television in October 1954, Robert Young was the only member of the radio cast to make the transition to the TV sitcom adaptation.
(November 22, 1963) When New Yorkers first witnessed breaking news of John F. Kennedy's assassination over WABC-TV, "Father Knows Best" was interrupted to make way for the unfolding news coverage.