- James Brolin was attached to play the Col. Samuel Trautman role after Richard Crenna died, but the role was written out of the script.
- Stallone originally set out to make this film before Rocky Balboa (2006), but Rocky was green-lighted by MGM, and he had to put Rambo on hold.
- This is the first Rambo film to be directed by Sylvester Stallone.
- This is the first Rambo film without a score composed by Jerry Goldsmith.
- During its long development process, 'Rambo' went through a number of story premises. One un-produced script featured Rambo living a quiet life with wife and child, until white supremacists kidnap his family. Another script found Rambo trying to stop a hostage situation at the United Nations, where he is working as a diplomat, when terrorists (including Rambo's adopted son) take hold of the UN headquarters in New York.
- Has a kill count of 236, the most for any Rambo film.
- This is the first Rambo film in the series that does not feature a companion novel written by Rambo's creator David Morrell. Morell wrote the novel "First Blood" on which that movie was based, and subsequently wrote novelizations of the 'Rambo: First Blood Part II' and 'Rambo III'. No novelization has been published for 'Rambo'.
- Ted Kotcheff who directed First Blood (1982), the original of the Rambo series, acts as a technical consultant on this particular installment.
- Because in many countries outside the USA the first installment, First Blood (1982) was titled as "Rambo", the title for the fourth installment had to be changed accordingly. In several countries, including France and Germany, the film is called "John Rambo". In Russia, the film's title is "Rambo 4".
- Julie Benz was cast as Sarah because Sylvester Stallone was a big fan of the TV show "Dexter" (2006) in which she stars.
- Although banned in Myanmar (formally Burma) by the military government, bootlegs of the movie are a hot item. Burmese Freedom Fighters have even adopted dialogue from the movie (most notably "Live for nothing, or die for something") as rallying points and battle cries. "That, to me," said Sylvester Stallone, "is one of the proudest moments I've ever had in film."
- Averages 2.59 killings per minute.
- Odeon, a UK cinema chain with more than 100 screens nation-wide, refused to show the film at their theaters because of 'commercial reasons'.
- Originally, Rambo was supposed to hold the M2 .50 caliber machine gun in his hands and fire it, but when fully assembled the .50 weighed 120 lbs. Stallone was still capable of holding and firing it but it was too cumbersome for quick movements, so they mounted it on the back of a jeep instead.
- During the montage after Rambo is asked to transport the mercenaries, it shows the alternate ending to First Blood (1982) where Col. Trautman ends Rambo's revenge on Teasle by shooting him in the abdomen.
>>> WARNING: Here Be Spoilers <<<
Trivia items below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- SPOILER: Although he died in 2003, Richard Crenna appears in this film through archive footage (Rambo's nightmares). With that respect, this is Crenna's final film appearance.
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